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All animal studies were performed in accordance with the institutional guidelines for the care and use of laboratory animals, national regulations, and the ARRIVE guidelines ( Osteoarthritis was induced in six-week-old male C57BL/6 mice through destabilization of the medial meniscus (DMM) surgery

Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, et al

Together, these advances suggest that MuSC aging is neither purely stochastic nor immutable

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The bulkier proline occupies more of the S1 pocket than does alanine, which explains the higher affinity for peptides with proline versus alanine at the second position