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You get a nice drop in blood pressure with no hypoglycemia. Pioglitazone has similarly shown a durable HbA1c reduction over 5 years and also improves insulin secretion and insulin sensitivity, reverses lipotoxicity and improves markers of nonalcoholic fatty liver disease, DeFronzo said

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Primary pulmonary hypertension: Phentermine has been associated with primary pulmonary hypertension, a rare but often fatal condition that may present with shortness of breath, chest pain, passing out, or leg swelling

10.1016/0022-3956(94)90006-X 260

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