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For semaglutide, these studies showed that: Refrigeration significantly slows chemical degradation Room temperature storage before first use increases the risk of reduced potency Long-term exposure to heat can shorten shelf life This is why regulatory agencies and manufacturers emphasize refrigeration until the medication is first used

GLP-1 is released far down in the digestive tract by special cells called L cells

Resulting P values were also corrected for multiplicity of comparisons (BenjaminiHochberg)

Fox News Digital reached out to Novo Nordisk and the FDA for comment.

stool softeners or gentle laxatives may be used if needed