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However, in AP/CP there is marked increase in GLP-1R, primarily in PSCs

Your dose stays the same, but your health care provider may increase the spacing between doses

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While higher doses (e.g., 20mg) are studied for maximal weight loss, the 10mg formulation provides an ideal concentration for dose-response analysis, receptor saturation studies, and mechanistic investigations into the contribution of each receptor subtype

SGLT2i, on the other hand, induce hemoconcentration through osmotic diuresis and increase hematocrit, raising theoretical concerns regarding thrombosis [16,17,18]