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When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself

doi: 10.1016/j.fertnstert.2009.08.065

6,10,11,12 The pathogenesis of DN is multifactorial and remains poorly understood

Although, rare, but it can also cause adverse effects on many organs including heart, lungs, muscles, skin and nerves too

It is also worth noting what research does not exist: there are no reproductive- or developmental-toxicology studies, no studies in hepatic or renal impairment, and no drug-interaction studies for 5-Amino-1MQ