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N-acetylcysteine Pharmacology and Applications in Rare DiseasesRepurposing an Old Antioxidant

It should be noted that in addition to the Na + -dependent and Na + -independent GSH transporters, MRP (multidrug resistance-associated proteins), CFTR (cystic fibrosis transmembrane conductance regulator), and organic-anion-transporting polypeptide (OATP), especially oatp1 in OATP family, can also transport GSH [38] in addition to GSH derivatives such as glutathione disulfide (GSSG), glutathione S -conjugates, glutathione and metal complex [38]

As such, there is no agreed recommended safe dosage, and some side effects might occur depending on individual response

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It plays a critical role in cellular protectionneutralizing free radicals and detoxifying cells