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While mild, transient lightheadedness may resolve spontaneously or with simple interventions, certain presentations warrant prompt medical evaluation

New side effects like burping or sulfur-tasting reflux can occur from GIP activation

A random-effects analysis was not conducted as there were no pairs of treatments in the evidence network supported by more than one trial, which would result in poor estimates of the distribution of intervention effects [33]

At 5 mg weekly, the SURMOUNT-1 trial showed average weight loss of 16% over 72 weeks

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