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The structural modification substituting a hydroxyl group where MT-II carries an amide was designed during Palatin Technologies' development program to concentrate therapeutic effects at MC3R and MC4R while stripping out the tanning and dermatological risk that come with strong MC1R agonism

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The agonistic activity of these hybrids were obtained by functional assays using cells expressing the GLP-1R and by measuring the receptor-mediated cAMP produced

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