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The mechanism of action of all these technologies to generate plasma is initiating and sustaining electron collision under their specified conditions, such as photoionization, radio frequency, and gas discharge (Ozen & Singh 2020)

In the early 20th century it was noted to lower blood glucose concentrations in animals, but it was not until the 1950s that Jean Sterne studied dimethylbiguanide and subsequently developed Glucophage [2]

Rottiers R, Veglio M, Fuller JH: EURODIAB Prospective Complications Study Group: Risk factors for progression to proliferative diabetic reti-nopathy in the EURODIAB Prospective Complications Study

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chloroquine, an autophagy inhibitor, diminished these beneficial effects of vildagliptin (Murase et al., 2015)