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In both cases, the spheroids were engineered with the goal of serving as building blocks for cardiac tissue patches intended for future grafting into damaged native myocardium and aid in the treatment of heart failure

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All treatments of mice in this study were in strict agreement with guidelines on ARRIVE and recommendations from an NIH-sponsored workshop regarding experimental design and reporting standards ( Cell Culture and Transfection RAW264.7 murine macrophage-like cells and THP-1 cells (human acute monocytic leukemia cell line) were obtained from the CBCAS (Cell Bank of the Chinese Academic of Sciences, Shanghai, China)

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