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These ROS exert substantial oxidative pressure on surrounding cellular structures, particularly on cell membranes rich in polyunsaturated fatty acids (PUFAs) (24)

Several classes of GST have been shown to exhibit non-catalytic ligand binding in the dimer interface 13,15

Most antioxidants sit on one side of a cell membrane or the other

Chem.272, 12,74712,753

Additionally, a study has shown that dexamethasone (DEX) induces glucocorticoid-induced osteonecrosis and MC3T3-E1 cells ferroptosis by regulating P53/SLC7A11/GPX4 axis (43), indicating that this pathway may be a potential strategy for treating osteoporosis