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In clinical and applied settings, there is a need to transition from generalized, one-size-fits-all approaches toward more individualized, cycle-aware strategies that account for temporal metabolic variability

This fundamental understanding has directly catalyzed a paradigm shift in therapeutic development, moving from widespread insulin replacement to targeted interventions aimed at addressing the root causes of the disease

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For the kind of stacked, accumulated wear-and-tear most adults bring into the clinic, the combination tends to work better