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Both in vitro and in vivo studies showed that knockdown of either the H or L subunits of ferritin in GBM CSCs markedly reduced cellular growth, as well as their capacity to form tumors in orthotopic models, which supports the role of ferritin as a key player in the proliferation and invasion of CSCs [3]

5-Amino-1MQ , while still in early stages, has demonstrated compelling effects in preclinical models