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Synergistic glutathione depletion and STING activation to potentiate dendritic cell maturation and cancer vaccine efficacy

The GSH levels of the BSO-treated cells quantified using our RT-based flow cytometry method is well correlated to the values measured using cell lysates with a glutathione reductase-based biochemical assay ( R 2 =0.99, Fig

Other contributors to this work include co-first authors Premranjan Kumar, Ob Osahon and David Vides, as well as Nicola Hanania and Charles G

Dosing too high or too low diminishes results, especially when using injections daily