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J Sep Sci 37(12):3036 Funding Financial support provided by American University of Beirut, Lebanon, through University Research Board (URB) as well as Kamal A

Key loci include immune-modifying genes such as human leukocyte antigens (HLA class I and II) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)

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Moreover, despite the similarity in structure, IGF-1 and insulin show different distribution in tissues, different internalization kinetics and different subcellular distribution of hormonal receptors

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