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Ma Y, Huang L, Zhang Z, Yang P, Chen Q, Zeng X, et al

PMID: 53 RoyRRamamoorthySShapiroBDKailehMHernandezDSarantopoulouDet al

One vial, four weeks, done

5.2.2 Mitochondrial dysfunction Ketamine disrupts mitochondrial function by reducing the membrane potential, increasing cytochrome c release, and promoting ROS generation, which collectively induce neuronal apoptosis ( Human studies have identified metabolic abnormalities in ketamine abusers, particularly in the prefrontal cortex, which may reflect mitochondrial dysfunction (Liao et al., 2011)