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PMID 11441390 Carr AC, Maggini S

Inflammation : Chronic inflammation or joint discomfort

The mechanisms of action involve modulation of sleep-regulating neurotransmitters and neuroendocrine systems including enhancement of delta wave activity during deep sleep stages, regulation of cortisol and stress hormone rhythms that impact sleep quality, optimization of circadian rhythm signaling for proper sleep-wake cycles, support for melatonin and sleep-promoting pathways, and modulation of pain perception which can interfere with sleep quality

Establishing a standard operating procedure for light and moisture control is therefore a wise precaution, ensuring that every member of the research team follows consistent practices

After this period, responders to the combination therapy were randomized to either continue Esoxx Defence alone or receive no further medication