In rats, chronic hypoxia during pregnancy induces an increased vasoconstrictor response to angiotensin II and acute hypoxic challenges in fetoplacental vessels (Tissot van Patot et al., 2003), mouse and ewe models of gestational hypoxia showed an increase in the capillary network in the placenta (Parraguez et al., 2006
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Some people tolerate the starting dose well and only experience symptoms later when the dose increases
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