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Important safety considerations include: Gastrointestinal symptoms: Eating smaller, more frequent meals and avoiding high-fat foods may reduce nausea and vomiting Hypoglycemia risk: Particularly when combined with insulin or sulfonylureas

The minimum time at each dose level is four weeks

The strongest dietary evidence in AF supports a Mediterranean-style pattern, both for general heart health and as part of the structured weight management used in trials like LEGACY

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Metabolic health: Patients with insulin resistance or metabolic syndrome may respond differently