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Requires IGF-1 baseline and physician evaluation

3.0 to 4.0 liters for men

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Additional support for the importance of gut-mediated mechanisms for metformins actions is the knowledge that IV administered metformin is ineffective in lowering hyperglycemia and was demonstrated using a hyperglycemic clamp technique to determine the relationship between plasma metformin concentration and hepatic glucose production and disposal in T2DM patients (92)