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Design, synthesis, and evaluation of -phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of -glutamyl transpeptidase

Abstract Because reactive oxygen species (ROS) have been implicated as mediators of inflammatory bowel disease (IBD), the purpose of the present work was to determine the functional role of mucosal GSH in the trinitrobenzenesulfonic acid in 50% ethanol (TNBS+ethanol)-induced colitis in rats

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Mark Krause, the labs jovial, broad-shouldered director, walked me past dishwasher-size chromatography and mass-spectrometry machines