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By taking the negative logarithm of the p -values from the enrichment analysis and filtering for pathways significantly enriched in both the transcriptomic and proteomic data, key pathways such as protein digestion and absorption and the PI3K-Akt signaling pathway were identified

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Transitioning to maintenance dosing (0.25mg twice weekly) instead of stopping abruptly sustains 8085% of peak pigmentation indefinitely JAMA Dermatology research found biweekly dosing retained colour for up to 60 days without further loading