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Topical steroids and antihistamines may be needed

This combines Tranexamic Acid, Alpha Arbutin, Kojic Acid, and Niacinamide to inhibit melanin production and reduce melasma and stubborn dark spots

The intervention yielded markedly significant enhancements in fatigue, diminished motivation, and anhedonia, alongside notable improvements in sleep disturbances, particularly those occurring in the middle of the night and early morning insomnia

Fmoc deprotection was achieved with 20% piperidine in DMF (twice for 2 min, room temperature, 300 rpm shaking) and peptide couplings were performed as double or triple couplings (twice for 5 min, 75 C, 300 rpm shaking, except for Arg and His, for which twice for 5 min, 50 C, 300 rpm shaking) consisting of AA/HCTU/DIPEA (ratio, 1:1.25:2.5) in fivefold excess compared to the resin

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