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This modification allows the peptide to bind to amylin receptor subtypes 1 and 3 in the brain, specifically in the area postrema of the hindbrain, producing sustained appetite reduction without the peaks and valleys that come with shorter-acting compounds

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The significant decrease in arachidonic acid, octadecadienoic acid, DHA, glycerophosphate, and 3-hydroxybutyrate in cardiomyocytes indicated that L-carnitine combined with trimetazidine affected the metabolism process of lipids and promoted oxidation and metabolism of fatty acids, as well as the production of ATP, and reduced the accumulation of fatty acids and the use of 3-hydroxybutyric acid