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Collectively, the nanoscale size, surface charge, and PDI support the stability and biological compatibility of QCN-HS

This mechanistic debate has been addressed in subsequent literature as reflecting differences in cell culture conditions, peptide batches, and choice of IGF-1 axis inhibitors and does not invalidate the substantial positive evidence base but represents an important research context requiring careful experimental design

Cognitive, emotional and social factors are critical determinants of self-care behaviours and, consequently, treatment success [165, 166]

Aggregate data are available from the authors upon reasonable request

Animals were allowed to take water and food freely