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Coronary atherosclerosis initiates with endothelial damage to the vascular intima, followed by a sequence of events including lipid deposition, vascular smooth muscle cell proliferation, and extracellular matrix synthesis, collectively resulting in arterial wall thickening and progressive luminal narrowing (17)

Combination Synergy: The success of CagriSema shows that combining amylin receptor agonist mechanisms with GLP-1 pathways produces superior results in obesity models compared to either mechanism alone

However, a prospective study in Iceland [19] reported that the prevalence of hepatoxicity was higher in men than in women

Women during this period experience worsening mood, anxiety, and sleep disruption, as well as declines in body satisfaction, self-esteem, and quality of life