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Lagan AS, Garzon S, Unfer V

Selectively increased leptin transgene expression is induced by a single icv injection of adeno-associated viral vectors encoding leptin (rAAV-lep)

Much of what is labeled lean mass loss reflects changes in water, glycogen, liver mass, and intramuscular fat rather than contractile muscle

Eight weeks of exposure to WD at middle-age increased brain cytokines in a sex-dependent manner, in which females demonstrated increased inflammation in the amygdala in response to WD, whereas males trended towards increased levels in the ventral hippocampus

Constipation Another common complaint when taking these medications is constipation or bloating