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Figure 3 Bone marrow mesenchymal stem cells differentiate into osteoblast progenitors under the stimulation of cytokines such as insulin-like growth factor 1 (IGF-1) and TGF- ( Figure 3 ) ( 2.3 T cells Autoreactive T cells that have escaped negative selection in thymus are the third cellular source for the joint inflammation and destruction ( + T cells play an important role in the induction and progress of RA, especially the imbalance of Th1/Th2 and Th17/Treg ( Figure 4 )

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