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Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6 J mice
17 The maintenance of iron homeostasis plays a key role in vital processes such as erythropoiesis, energy metabolism of muscle, cell cycle regulation, hormone production, immune system function, heme synthesis, DNA replication and repair, brain development and aging, and the formation of cytochromes
Celastrol has reportedly alleviated CKD by upregulating cannabinoid receptor 2 (Tang et al., 2018)
Interestingly, reintroducing cytoplasmic GPX4, rather than its mitochondrial or nuclear counterparts, can rescue the lethal phenotype in Gpx4 -null mice [119]