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In addition, preoperative digestive symptoms (nausea, vomiting, dyspepsia, abdominal distension) and semaglutide use within the 30 days prior to EGD were shown to increase the risk of increased RGC by 5.15 and 3.56 times, respectively

On the other hand, clozapine, an established anti-impulsivity drug, was found to directly alter the expression of leptin and adiponectin genes (3537)

In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)

But shortages can still happen, especially with semaglutide