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10.1681/ASN.2013020134 159

Indications / Uses Entacapone is used in: Parkinsons Disease For patients taking Levodopa/Carbidopa who develop: End-of-dose wearing off Motor fluctuations Reduced duration of levodopa response Not used in early Parkinsons alone

In isolated mouse islets, neutralizing GIP immune responses led to a reduction in glucose-stimulated insulin secretion, aligning with the idea of local release of an insulinotropic GIP peptide from -cells [20]

Conversely, although off-label use of GLP-1 RA for overweight and obesity cannot be excluded, such use was likely limited in the present study given existing prescription guidelines and regulatory vigilance

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