Violett B, Horman S, Leclerc J, et al
Certain batches were found out of specification due to an impurity linked to a reaction-related process in that API lot
One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)
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This year, clinical studies showed that they also reduce symptoms of heart failure and the risk of heart attacks and strokes, the most convincing evidence yet that the drugs have major benefits beyond weight loss itself," the journal concludes