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Future studies will therefore focus on expanding mechanistic validation, conducting extended safety assessments, and optimizing formulation and delivery strategies to support further translational development

For example, studies performed in murine J774A.1 macrophages showed that TMAO induced stress and led to increased protein expression of GRP94 and HSP70, which may participate in the abnormal activation of macrophages involved in foam cell formation (Mohammadi et al., 2018)

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Ann Surg Oncol (2013) 20:32339