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Ethics declarations Ethics approval and consent to participate All experiments with brain organoids were performed in accordance with the national and international ethics guidelines, and were approved by the ethics committee at the University of Luxembourg, Comit National dEthique de Recherche (CNER

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At the time of writing, APAP is probably the most widely available and commonly used drug worldwide and represents a very important analgesic;1 indeed it is included in the 20 th World Health Organization Model List of Essential Medicines as updated in March 2017.2 Some 60 years after its introduction as a therapeutic agent in the UK, APAP remains a compound of great interest, not only because of its therapeutic properties but also for its ability to cause hepatotoxicity in overdose