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glutathione system and glutathione-dependent enzymes.5 The balance of glutamate and GABA neurotransmitter systems activity, which provides general control and fine-tuning of the excitation, is, similarly, disturbed in depression.6 Activity of glutamate dehydrogenase (GDH) is of paramount importance in the brain glutamate system functioning7 with altered platelet GDH reported in mental disorders.8 Disturbances of the respiratory mitochondrial chain, complex IV (cytochrome c-oxidase - COX), can also contribute to depression.9The aim of this study was to both determine enzymatic activities, such as COX, GDH, glutathione reductase (GR) and glutathione-S-transferase (GST), in platelets and GR, and GST in erythrocytes in older patients with depression and determine their clinical relevance to aid person-centered treatment

doi: 10.3390/pharmaceutics17020190 168 MahmoudiAKesharwaniPMajeedMTengYSahebkarA

Deciphering brain insulin receptor and insulinlike growth factor 1 receptor signalling

Candido R, Gaiotti S, Giudici F, et al