A clear determination and overview of genes, which are up- and downregulated during copper stress in the tested species within this study is not given and, therefore, poses a limitation of this study
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For example, BD patients exhibit high plasma levels and brain mRNA expression of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor- (TNF-) [28], and high acute phase reactants, such as C-reactive protein (CRP) [124]
As with many medications, ongoing research is needed to fully understand the long-term implications of its use
Elsevier, Oxford, UK, pp 733737 Dringen R, Gutterer JM (2002) Glutathione reductase from bovine brain