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FIGURE 3 Clinical studies have reported controversial results despite the support from preclinical studies (Table 2)

Adding coverage for semaglutide would cost Medicare $26.8 billion annually, and insurance premiums likely would go up, according to a study published in the New England Journal of Medicine

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All seven investigations point in the same direction on the forest plot, and the fact that the confidence intervals for each research are completely to the left of the null line (0.00) suggests that this conclusion is robust (Figure 5)