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In a 2024 cryo-EM structure paper published in Cell Discovery, researchers resolved retatrutide bound to each of the three receptors and showed the same peptide adopting a continuous alpha-helical conformation across all three, with receptor-specific contacts in the extracellular loops that tune potency at each target

Comprising 15 amino acids with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, BPC-157 has become one of the most widely referenced research peptides in preclinical literature

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