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Recent advances in peptide engineering have moved beyond the combination of multiple agents, as seen with compounds like tirzepatide, which act on several receptors simultaneously with a single peptide, emulating the effects of combination therapy

Urenjak J, Obrenovitch TP

Most experiments examining the metabolic actions of DPP-4 on glucose and lipid metabolism have been carried out in younger mice

Pharmacological inhibition of adipose tissue adipose triglyceride lipase by atglistatin prevents catecholamine-induced myocardial damage

The pancreatic peptide hormones guide provides context on how incretin-based compounds interact with endogenous hormone systems