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In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 11% of the total weight of the formulation

Although the precise molecular mechanisms remain largely elusive, we will describe how ceramides target mitochondria function in brain by several mechanisms: (1) changes in the lipid composition of the mitochondria membrane, (2) alteration in mitochondrial respiratory chain activity and increased in ROS production, and (3) changes in mitophagyapoptosis process

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