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There is insufficient evidence to recommend the use of metformin as targeted therapy for MASH, but it is safe in patients with MASLD and should be used for its respective indications, namely T2DM, heart failure, and chronic kidney disease 54

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For product developers, this shifts the discussion from simply adding berberine to designing a system that can manage stability, release profile, tolerability and effective delivery

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There was an increased rate of hypoglycemia in patients treated with JANUVIA

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Access at present is therefore limited to participation in regulated clinical trials

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Helps reduce fatigue and supports recovery after intense workouts

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