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Phase 3 data showed weight loss of 7.5% to 11.2% at 72 weeks depending on dose, with head-to-head data showing orforglipron 36 mg producing 73.6% greater weight loss than oral semaglutide 14 mg

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Both require medical oversight for safe use, and the right choice depends on individual response, dose tolerance, side-effect profile, and prescriber assessment rather than the reputation of one active ingredient alone

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