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A proteolysis-resistant MRI-visible nanoparticle formulation of GLP-1RA (nano-GLP-1RA) was engineered to target GLP-1Rexpressing cells within atherosclerotic lesions ( In ApoE/ mice, nano-GLP-1RA selectively accumulated in plaque-resident inflammatory and de-differentiated smooth muscle cells, consistent with GLP-1Rexpressing populations observed in human plaques ( Taken together, while imaging and omics technologies offer powerful tools to characterize vascular biology, their integration with GLP-1RA therapy for patient stratification remains an emerging concept that requires further clinical validation