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To evaluate changes in hepatic synthetic function and the development of hepatic decompensation, serial monitoring of Child-Turcotte-Pugh (CTP) score, model for end-stage liver disease (MELD) score, and new onset or worsening of liver-related events such as ascites, variceal bleeding, hepatic encephalopathy and HCC are needed

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Cardiovascular effects: Phase 2 trial data indicate that retatrutide was associated with modest increases in resting heart rate, consistent with observations seen with other GLP-1 receptor agonists

Accessed 05/09/2022