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NRF2 stimulates the production of heme oxygenase-1 (HO-1) and the accumulation of Fe 2+ in LIP as well as the release of iron from hemoglobin, hence inducing ferroptosis

It protects the brain and acts as a free radical scavenger and inhibitor of lipid peroxidation

However, PGE2 is known to play a dual role, as it can both suppress the immune response against M.tb and protect the host from excessive inflammation, suggesting that NSAIDs should be exercised with caution for TB treatment [128]

Hypothetical research combination

While most patients are successfully treated with levothyroxine alone, some patients' complaints do not fully improve with levothyroxine