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Building upon the established effects of GLP-1 receptor agonists, dual GCG/GLP-1 receptor agonists simultaneously improve the two core pathogenic mechanisms of diabetes - insufficient insulin secretion and insulin resistance, thus, delivering comprehensive benefits beyond glycemic control, including weight loss, and hepato-cardio-renal metabolic improvements

Making patients aware of both benefits and limitations shapes their expectations and helps to mitigate disappointment or avoid overuse, he said.

International Journal of Cosmetic Science 27(3):155-160. [doi.org]

This multi-mechanism approach often produces sustained weight loss beyond the initial 12-week window, with many patients maintaining benefits for years