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Common Side Effects and How Adjusting Timing May Help Side effects can affect when people choose to take their injections

About 20 to 30 percent of patients experience moderate nausea that interferes with meals but does not prevent daily activities

Due to its dual action on Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), tirzepatide is more effective than semaglutide at promoting weight loss, but both drugs are associated with a significant reduction in body weight

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Both are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, also called MEN 2