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E., Carling, D., et al

Conclusion: These results suggest that disturbance of the gut microbiota may take participate in the progression of PCOS and manipulating the composition of the gut microbiota may be a therapeutic approach for managing PCOS

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Deletion of PLC-3 or PLC-4 genes showed no phenotypic effects in mice, but sperms from PLC-4-deficient mice showed a defective acrosomal reaction, a process required for fertilization (Fukami et al., 2001