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Lactic acidosis reports were markedly lower with combination therapy (567 vs 15,789), as were acute kidney injury (675 vs 7,694), diarrhoea (3,890 vs 6,922), and metabolic acidosis (203 vs 4,713), suggesting that the addition of GLP-1 RAs to metformin may mitigate serious adverse effects associated with metformin alone (Table 2)

It is significantly more potent and has a targeted effect on visceral fatthe deep abdominal fat that surrounds internal organs and drives inflammation and metabolic disease

Alternative and New Treatments Goldberg discusses exciting immune therapies, including dendritic cell therapy, which shows promise in cancer treatment

FDA does not evaluate compounded medications for safety, effectiveness, or quality before marketing

Mol Cells (2018) 41(3):23443