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Vitamin B12 shots are a particularly good option for people who cant manage their vitamin B12 levels without making any dietary changes, are older, have had weight loss surgery, and take certain medications

Congruently, we found increased CD68 + macrophage infiltration in adipose tissue of obese compared with lean individuals confirming local fat inflammation, but they did not correlate with circulating MOTS-c levels, dissociating MOTS-c from local immune cell infiltration

[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

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